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مشاهدة النسخة كاملة : Virtual Screening in Drug Discovery


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09-11-2006, 10:14 PM
Virtual Screening in Drug Discovery



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Book Properties
ISBN: 0824754794
Title: Virtual Screening in Drug Discovery
Author:
Publisher: CRC
Publication Date: 2005-03-24
Number Of Pages: 496
Average Amazon Rating: 5.0

With millions of compounds available for screening and thousands of gene products as potential targets for therapeutic intervention, high-throughput screening (HTS) requires extensive libraries and automated screening systems to discover adequate leads for drug development. This can become expensive, and in recent years has proven minimally effective. Virtual screening uses computational tools to identify biologically active molecules against specific targets. By pre-qualifying compounds for testing, this method reduces costs and increases hit rates by eliminating the need for robotics, reagent acquisition or production, and compound storage facilities. This text explores the algorithms involved and their uses in virtual screening.


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