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04-11-2006, 08:31 PM
Role of gut bacteria in human toxicology and pharmacology
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by Bradley Hillman
Hardcover: 286 pages
Publisher: CRC (April 27, 1995)
ISBN: 0748401105
From the Introduction:
... The most richly colonized site in the human body is the digestive tract and, particularly, the large intestine. ... Consequently, the gut bacteria are in a highly favourable position to mediate between a person and their surrounding environment by interacting not only with the undigested food components but also with the full range of xenobiotics that reach the gut in the form of food additives, drugs, environmental contaminants and so on, either directly or after biliary secretion in the form of conjugates. Their importance in toxicology and pharmacology, although first noted and publicized many decades ago, is still only slowly being realized and fully recognized.
... In this book the first Section deals with background data on the normal gut bacterial flora and its metabolic activity, and the use of gnotobiotic animals in toxicology. The second Section is concerned with various aspects of nitrogen metabolism. Section 3 covers carbohydrate metabolism and the toxicology of the end-products of fermentation. Section 4 deals with the metabolism of fats and fat substitutes; the chapter on fats includes data on bile acid metabolism since the bile acids are so crucial to efficient fat digestion. Section 5 is about the metabolism of sulphur compounds and
about sulphatereducing bacteria. Section 6 is concerned with a miscellaneous group of compounds, and includes discussion of the metabolism of metal compounds and the production of vitamins by the gut flora. Section 7 covers the crucial area of the biliary excretion and enterohepatic circulation of xenobiotics. The final Section reviews the general area of probiotics; this is clearly an area that will grow rapidly over the next few years because probiotics offer a constructive route to combating the role of gut bacteria in toxicology, rather than the essentially destructive route of antibiotic use.
http://rapidshare.com/files/1971183/ROGBIHUTAP.rar.html
pass: tFROGBIHUTAP.rar
http://www.s966.info/up/uploads/cb93108aa2.jpg (http://www.s966.info/up)
by Bradley Hillman
Hardcover: 286 pages
Publisher: CRC (April 27, 1995)
ISBN: 0748401105
From the Introduction:
... The most richly colonized site in the human body is the digestive tract and, particularly, the large intestine. ... Consequently, the gut bacteria are in a highly favourable position to mediate between a person and their surrounding environment by interacting not only with the undigested food components but also with the full range of xenobiotics that reach the gut in the form of food additives, drugs, environmental contaminants and so on, either directly or after biliary secretion in the form of conjugates. Their importance in toxicology and pharmacology, although first noted and publicized many decades ago, is still only slowly being realized and fully recognized.
... In this book the first Section deals with background data on the normal gut bacterial flora and its metabolic activity, and the use of gnotobiotic animals in toxicology. The second Section is concerned with various aspects of nitrogen metabolism. Section 3 covers carbohydrate metabolism and the toxicology of the end-products of fermentation. Section 4 deals with the metabolism of fats and fat substitutes; the chapter on fats includes data on bile acid metabolism since the bile acids are so crucial to efficient fat digestion. Section 5 is about the metabolism of sulphur compounds and
about sulphatereducing bacteria. Section 6 is concerned with a miscellaneous group of compounds, and includes discussion of the metabolism of metal compounds and the production of vitamins by the gut flora. Section 7 covers the crucial area of the biliary excretion and enterohepatic circulation of xenobiotics. The final Section reviews the general area of probiotics; this is clearly an area that will grow rapidly over the next few years because probiotics offer a constructive route to combating the role of gut bacteria in toxicology, rather than the essentially destructive route of antibiotic use.
http://rapidshare.com/files/1971183/ROGBIHUTAP.rar.html
pass: tFROGBIHUTAP.rar